Chondroitin sulphate is a sugar chain found in cartilage, bone, skin and other connective tissue. In a human cartilage cell line it lowered MMP-2 and MMP-9 and raised the inhibitors TIMP-1 and TIMP-2.
Also called chondroitin sulphate, CS.
Chondroitin sulphate occurs in human cartilage, bone, cornea, skin and artery walls, and is part of the basic substance of connective tissue matrix (Hsu 2022).
The study on this site is from 2022. Hsu and colleagues treated chon-001, a human cartilage cell line, with chondroitin sulphate (Hsu 2022). The cells multiplied and migrated more. Type II collagen and the MMP inhibitors TIMP-1 and TIMP-2 rose, and MMP-9 and MMP-2 fell in both amount and activity. Activation of the Akt and NF-kB signalling routes dropped (Hsu 2022). The abstract doesn't give the concentrations used.
That study didn't measure MMP13, and no study on this site tests chondroitin directly against it. Evidence for chondroitin and MMP13 specifically is missing here, not negative.
The lab evidence is thin and mixed. Glucosamine lowered MMP13 in one study of human cartilage cells and stem cells, but in another it didn't change cytokine-driven...
In two main ways. Cells release MMP13 as an inactive proenzyme that must be cut before it works, and the body makes its own inhibitors, the TIMPs. TIMP-1, TIMP-2 and...